
Epidermis (epithelial tissue, avascular, enervated

5 layers

Stratum Basale

This is where rapid cell division occurs

Stratum Spinosum

Cell division occurs in deepest portion

Stratum Granulosum

Keratinization begins

Stratum Lucidum

Only present in thick skin (palms/soles)

Stratum Corneum

Highly keratinized top layer

Specialized Cells

Dendritic Cells

Phagocytes in stratum spinosum,
communicates with lymphatic system

Tactile Cells

Corresponds with sensory nerve ending in stratum basale
responds to light touch

Melanocytes

Melanin producing cells in stratum basale,
extension project into other layers

Disease related to epidermis

Skin Cancer

Basal Cell

Squamous Cell

Melanoma

Psoriasis

Cells divide more frequently,
results in red patches with silvery scales

Decubitus ulcer

Blood supply occluded

Dermis (connective tissue, vascular, innervated

2 layers

Papillary Region (fingerprints)

Contain dermal papillae, Increase surface area between epidermis,
most abundant in hands and feet

Reticular Layer (dense, irregular connective tissue)

Dense, irregular CT, contains collagen, elastin
connects epidermis to underlying tissue

Contains

Blood vessels

Supply fluid transfer to epidermis, regulate temperature

Muscle fibers

Erector pili muscle cells pull on hair follicle

Other smooth muscle cells move skin

Skeletal muscles anchor to dermis in face

Nerves

Afferent and efferent

Hypodermis/Subcutaneous/Superficial Fascia
loose areolar and/or adipose

Not part of the integument, but often discussed with

Accessory Organs (epithelial tissue)

Hair

Penetrates into the dermis

Nails

Glands

Suderiferous (Sweat)

Merocrine aka Eccrine (water perspiration)

Apocrine (viscous - found in axillary region, groin, areola)

Modified Apocrine

Cereminous (Ear Wax)

Mammary Glands (Breast milk)

Sebaceous (Sebum/Oil)